• International name (active ingredient): lithium carbonate
  • Manufacturing company: FAES FARMA
  • Country of manufacture: Spain
  • Release form: 400 mg tablet #100
  • Dispensing mode: II group (dispensed with form N3 prescription)


Composition of PLENUR:

  • Each tablet contains 400 mg. lithium carbonate (active substance);
  • Other ingredients are carbomer, sodium carmellose, magnesium carbonate, microcrystalline cellulose, glycerin, magnesium stearate, macrogol 6000, titanium dioxide (E171), methacrylic acid copolymer and ethyl acrylate, talc.

Plenur contains lithium carbonate as an active ingredient, an antipsychotic that is used as a mood stabilizer.
It is indicated to prevent and treat bipolar disorder (mood disorders in which seasons with depression alternate with seasons with great euphoria) and as an additional treatment in resistant major depression (repeated episodes of severe depression) in patients who have not had an optimal response to antidepressant treatmen


PLENUR is used to prevent and treat bipolar disorder (a disorder characterized by depression and major anxiety) and recurrent depression (repeated episodes of severe depression).


  • Are you allergic (hypersensitive) to lithium carbonate or any of the other ingredients of PLENUR
  • During acute renal failure
  • In severe heart disease
  • During sharp weakness and fatigue
  • During pregnancy or breastfeeding

Take special care when taking PLENUR in the following cases:

  • If you have excessive sweating
  • If you have diarrhea
  • If you are vomiting
  • If you have a high fever
  • If you have taken diuretics
  • If you have hypothyroidism or psoriasis

Consult a doctor even if any of the above circumstances have not occurred.

  • Renal tumors: Patients with acute renal failure who receive lithium for about 10 years are at risk of developing benign or malignant renal tumors (microcysts, oncocytomas, or renal ductal carcinomas).

PLENUR should always be used under the supervision of a physician. You should see your doctor regularly. To check the correctness of the treatment, your doctor should ask you to check the blood test periodically.

Use of other medications

  • Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
  • It is especially important to tell your doctor if you are taking diuretics to increase urine output (such as thiazide, acetazolamide or furosemide and bumetanide), haloperidol to treat certain nerve diseases, fluoxetine used for depression, anti-inflammatory drugs (such as indomethacin, phenylbutazone or ibuprofen), anticonvulsants (such as carbamazepine and phenytoin), medicines for high blood pressure (such as captopril, enalapril and verapamil), muscle blockers used to relax muscles during surgery (such as succinyl or pancuronium), iodides ( such as potassium iodide) used in the treatment of asthma (such as theophylline) or sodium bicarbonate used in emesis.
  • Please also consider which medications you are taking before and after treatment with PLENUR.

Possible side effects

  • Like all medicines, PLENUR can cause side effects, although not everybody gets them.

Very common side effects (may affect up to 1 in 10 people)

  • Excessive or sudden urinary frequency may be detected at the beginning of treatment, at which time it is necessary to stop taking lithium. At this time, the level of calcium in the blood is increased.
  • Fatigue, tremors, muscle weakness, headache, slurred speech, confusion, impaired concentration, these are the events when it is necessary to stop using lithium. Stress and caffeine can exacerbate tremors.
  • Drowsiness: Usually disappears with time. If this is detected, take precautions when driving and using the vehicle.
  • There are not so serious abnormalities on the electrocardiogram: it is necessary to stop the treatment.

Common side effects (may affect up to 1 in 100 people)

  • Loss of appetite, which can lead to weight loss.
  • Nausea, vomiting, diarrhea or constipation, abdominal pain: these symptoms usually disappear within a week of using the medicine.

If these symptoms persist or become more frequent, consult your doctor immediately.

  • Hypothyroidism (enlarged thyroid gland), goiter (enlarged thyroid gland).
  • Muscle tension, excessive reaction during stimulation, increased muscle tone.
  • During the increase of white blood cells, it is necessary to stop the treatment.

Less common side effects (may affect up to 1 in 1,000 people)

  • Enlargement of the thyroid gland (the thyroid gland is located near the neck).
  • Weight loss.
  • Dizziness, vertigo, convulsions, transient loss of consciousness.
  • Rapid, uncontrolled eye movements, temporary loss of vision, nearsightedness.
  • Changes in heart rhythm, decrease in heart rate, decrease in tension
  • Blood, fluid retention and edema (edema), syncope (fainting)
  • Dry mouth, loss of taste
  • Acne, rash on the skin, spontaneous discontinuation of the drug is considered.
  • Kidney problems, increased amount of albumin and sugar in urine.
  • Impotence, sexual dysfunction.
  • Transient excess of sugar in the blood.

Rare side effects (may affect up to 1 in 10,000 people)

  • Psoriasis (a skin disease that is a red rash that is more pronounced on the scales of the elbows, knees and kneecaps). There are hair loss, brittleness and dryness, as well as shedding and itching in the hairy area. Skin ulcers or swelling of the skin, decreased skin sensitivity.

Very rare side effects (may affect up to 1 in 10,000 people)

  • Discoloration of the toes, while the heels are cold. In case of manifestation of the mentioned, it is necessary to stop the treatment.

Unknown rare events: benign or malignant kidney tumors (microcysts, oncocytomas and renal collecting duct carcinomas) – long-term treatment is necessary.

Contact your doctor immediately if you experience any of the above

The following symptoms:

  • Diarrhea, vomiting, fatigue, muscle weakness, decreased coordination or slurred speech.

Mutually exclusive side effects:

If you experience any side effects, please contact your doctor or pharmacist immediately, even if the latter possible side effects are not described in this instruction. You can also contact the Spain Pharmacy System directly at the following website:

How to get PLENUR

  • Follow your doctor’s advice exactly when using PLENUR. If you have any questions, ask your doctor or pharmacist.


  • The dose varies between patients. Your doctor will determine the dose based on lithemia (the amount and levels of lithium in the blood). The normal dose is determined by 1-4 tablets per day.

Lithium levels in the blood:

  • For lithium to be effective, you must have a certain level of lithium in your blood. Based on the results of the blood test, your doctor should be sure whether you have the required amount of lithium in your blood or whether the said amount is sufficient. Therefore, to prescribe treatment, it is necessary to conduct a blood test 1 or 2 times a week and then 1 or 2 times a month. The analysis must be performed before taking the medicine, if you have to take PLENUR in the morning, then it is necessary to take a blood test before taking the medicine.
  • Other blood tests may be done to check for possible harmful effects of lithium on the kidneys and thyroid.

Acceptance form:

  • PLENUR is taken orally. During the correct use of PLENUR, it is necessary to swallow the tablets whole, without chewing or breaking them, followed by water or a non-alcoholic drink. It is advisable to take the medicine with food.
  • If you think the effect of PLENUR is too strong or too weak, consult a doctor or pharmacist.

Use in children:

  • The use of PLENUR in children is not recommended.

Use in elderly patients:

  • In elderly patients, low lithium levels are necessary and frequent monitoring of lithium (lithium level in the blood) is required.
  • In patients on a low-salt diet, frequent control of lithemia (lithium level in the blood) is necessary.
  • In patients suffering from kidney disease and acute cardiovascular diseases, who use diuretics, during excessive fluid loss (excessive sweating, diarrhea, high fever), caution is required when using lithium.
  • In hypothyroid patients, maximum monitoring is necessary and additional thyroid treatment is also possible.

If you forget to take PLENUR:

  • Do not take a double dose.

If you stop taking PLENUR

  • Inform your doctor about the duration of treatment with PLENUR.
  • Do not stop treatment without consulting your doctor because your problem may recur or you may notice other symptoms.

If you have any other questions, ask your doctor or pharmacist.

  • Release form: 400 mg tablet #100

PLENUR modified release coated tablets, white, biconvex, round shape. Each package contains 100 tablets.

  • Dispensing mode: II group (dispensed with form N3 prescription)